2016

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Piperazine selenium nanoparticle (Pipe@SeNP’s): A futuristic anticancer contender against MDA-MB-231 cancer cell line, 2022

Drug resistance is a major drawback of breast cancer management mainly in treatment failure. The main objective of the current study is to investigate whether Piperazine selenium nanoparticles (Pipe@SeNP's) can induce apoptosis in breast cancer cell lines. Piperazine molecule (pipe) was synthesized and characterized using different spectral studies such as 1 H-NMR, 13 C-NMR, LCMS, and FTIR. Pipe@SeNP's was synthesized and amply characterized with UV-Vis spectra, FT-IR, SEM, EDX, XRD, and DLS highest size distribution was found to be 26.39 nm compared to other sizes with 3.8 mV zeta potential value. Before the synthesis of the Pipe@SeNP's, the core chemical was assessed for their Pharmacophore model, PASS, ADME, and BBB. All the computational assays strongly indicated the potency of the molecule. Pipe@SeNP's was treated with both normal (PBMC) and cancerous (MDA-MB-23) cell lines and investigated their dose optimization, and cytotoxicity by MTT and SRB assays. The colony morphological changes and cell proliferation inhibitory effect of Pipe@SeNP's were monitored up to 8 hrs against cancer and normal cell lines compared to etoposide drug with colony formation and scratch wound assay. The efficacy of normal and cancerous cell death patterns was examined in a flow cytometer. The data showed that 61.92% of cells were dead in the late apoptotic phase and 22.60% of cells in the early apoptotic stage compared to standard drug etoposide 13.41% of cells were in the early apoptotic stage, 47.48% of cells in the late apoptotic phase and 20.65% of cells undergo necrosis. This revealed data strongly indicated that, Pipe@SeNP's could be of great potential in futuristic drug development against breast cancer cells.

2016

International Journal of Nanomedicine Preparation of hippurate-zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on HepG2 cell lines

[1] Editorial board member of: International Journal of Industrial Chemistry (IJIC) Published by the Springer. em@editorialmanager.com http://www.springer.com/chemistry/industrial+chemistry+and+chemical+engineering/journal/40090?detailsPage=editorialBoard [2] Editorial board member of: E-Cronicon Chemistry (EC Chemistry) https://www.ecronicon.com/chemistry.php https://www.ecronicon.com/chemistry-editorial-panel.php [3] Editorial board member of: BAOJ Chemistry http://bioaccent.org/chemistry/index.php http://bioaccent.org/chemistry/editorialboard.php

International journal of nanomedicine, 2017

Rigorous peer-review is the main part in building the cornerstone of high-quality academic publishing. The editorial team greatly appreciates the authors, reviewers who contributed their knowledge and expertise to the journal's editorial process over the past 24 months. In 2019, a total of 11 articles was

Background: Copper oxide (CuO) nanoparticles have attracted huge attention due to catalytic, electric, optical, photonic, textile, nanofluid, and antibacterial activity depending on the size, shape, and neighboring medium. In the present paper, we synthesized CuO nanoparticles using gum karaya, a natural nontoxic hydrocolloid, by green technology and explored its potential antibacterial application. Methods: The CuO nanoparticles were synthesized by a colloid-thermal synthesis process. The mixture contained various concentrations of CuCl 2 ⋅ 2H 2 O (1 mM, 2 mM, and 3 mM) and gum karaya (10 mg/mL) and was kept at 75°C at 250 rpm for 1 hour in an orbital shaker. The synthesized CuO was purified and dried to obtain different sizes of the CuO nanoparticles. The well diffusion method was used to study the antibacterial activity of the synthesized CuO nanoparticles. The zone of inhibition, minimum inhibitory concentration, and minimum bactericidal concentration were determined by the broth microdilution method recommended by the Clinical and Laboratory Standards Institute. Results: Scanning electron microscopy analysis showed CuO nanoparticles evenly distributed on the surface of the gum matrix. X-ray diffraction of the synthesized nanoparticles indicates the formation of single-phase CuO with a monoclinic structure. The Fourier transform infrared spectroscopy peak at 525 cm −1 should be a stretching of CuO, which matches up to the B 2u mode. The peaks at 525 cm −1 and 580 cm −1 indicated the formation of CuO nanostructure. Transmission electron microscope analyses revealed CuO nanoparticles of 4.8 ± 1.6 nm, 5.5 ± 2.5 nm, and 7.8 ± 2.3 nm sizes were synthesized with various concentrations of CuCl 2 ⋅ 2H 2 O (1 mM, 2 mM, and 3 mM). X-ray photoelectron spectroscopy profiles indicated that the O 1s and Cu 2p peak corresponding to the CuO nanoparticles were observed. The antibacterial activity of the synthesized nanoparticles was tested against Gram-negative and positive cultures. Conclusion: The formed CuO nanoparticles are small in size (4.8 ± 1.6 nm), highly stable, and have significant antibacterial action on both the Gram classes of bacteria compared to larger sizes of synthesized CuO (7.8 ± 2.3 nm) nanoparticles. The smaller size of the CuO nanoparticles (4.8 ± 1.6 nm) was found to be yielding a maximum zone of inhibition compared to the larger size of synthesized CuO nanoparticles (7.8 ± 2.3 nm). The results also indicate that increase in precursor concentration enhances an increase in particle size, as well as the morphology of synthesized CuO nanoparticles.

CURRICULUM VITAE (C.V.), 2024

Prof. Loutfy H. Madkour is a Full Professor of Physical chemistry and Nanoscience at Tanta University (Egypt) and Al Baha University (Saudi Arabia).He is a contributing Researcher and Editor to Chemistry World. He has more than 20 years of experience in science: research, writing and editing in condensed-matter, Corrosion Science and Advanced Structured Materials relating to Nanoscience, Nanomaterials, Technology/Nanotechnology/Biotechnology, Cancer Nanomedicine, and Drug Delivery. He received his BSc, MSc, and PhD in Physical Chemistry from the Cairo, Minia, and Tanta Universities in Egypt, respectively. (h-index 24, Scopus Author ID: 57201889680, 2145 citations). He has conducted a series of studies in various areas of the field of Physical chemistry: electrochemistry, electroanalytical chemistry, corrosion science, density functional theory (DFT), molecular dynamic simulation, quantum chemistry, theoretical chemistry, chemical equalization principles, nanoscience, nanotechnology, nanomedicine, nanotoxicology, electrometallurgy, analytical chemistry, polarography, electrolytic extraction of heavy metals from natural ores and deposits, electrochemical thermodynamics, and environmental chemistry. His earlier research included the biosynthesis of metallic nanoparticles (MNPs) as well as toxicology studies for pharmacological applications in nanomedicine and therapy. He has published 200 peer-reviewed original research articles, 26 review articles, 5 book chapters and 11 books in the area of physical and environmental chemistry, advanced structural nanomaterials, corrosion science, nanoelectronics materials, cancer nanomedicine, drug delivery and nanotoxicology. He holds a number of different positions at universities in Egypt, Kuwait, Yemen, and Saudi Arabia.Prof. Madkour is appointed as the prestigious Editorial Board member of several international journals. His name has been listed in the top 2% of the most distinguished and influential scientists globally according to the ranking and database of Stanford American University of Scientists globally in (2022). He obtained Award: ISAO in the year (2022): "Lifetime Achievement Award" in the International Scientist Awards on Engineering, Science and Medicine. He obtained Awards: ISAO in the years (2022, 2021 and 2020): "Distinguished Scientist Award" in the International Research Awards on Science, Technology, and Management.He is an editorial board member of several international journals, including International Journal of Industrial Chemistry (IJIC-Springer), International Journal of Ground Sediment & Water, Global Drugs and Therapeutics, Chronicles of Pharmaceutical Science, Journal of Targeted Drug Delivery, UPI Journal of Pharmaceutical, Medical and Health Sciences, Global Journal of Nanomedicine, Clinical Pharmacology and Toxicology Research, Journal of Pharmacology & Pharmaceutical Research, LOJ Pharmacology & Clinical Research, CPQ Medicine, Pharmaceutical Sciences & Analytical Research Journal, Japan Journal of Research, Organic & Medicinal Chemistry International Journal, Nanotechnology & Applications, Materials Science Journal, Journal of Chemical Science and Chemical Engineering, United Journal of Nanotechnology and Medicine, Clinical Practice (Therapy), Journal of Materials New Horizons, Journal of Radiology and Medical Imaging (MedDocs Publishers), World Journal of Pharmacy and Pharmaceutical Sciences, Journal of Material Science and Technology Research, Ecronicon: EC Clinical & Medical Case Reports (ECCMC), Medical Research and Health Sciences, and Acta Scientific Women's Health Journal, PHARMACOGNOSY Journal, Journal of Community Medicine and Health Care Management, Environmental Degradation of Materials of Frontiers in Materials, Journal of Cancer Therapy and Research, Journal of Materials and Polymer Science, Journal of Clinical and Biomedical Investigation, Radiology & Imaging Journal, International Journal in Pharmaceutical Sciences (IJPS), EC Clinical and Medical Case Reports, BOHR International Journal of Pharmaceutical Studies (BIJOPS), General medicine and Clinical Practice, Journal of Gastroenterology Hepatology and Digestive Disorders, International Journal of Organic and Inorganic Chemistry, ACTA SCIENTIFIC PHARMACEUTICAL SCIENCES, Medvix publications LLC, International Journal of Cardiology Research & Reviews, International Journal of Nursing Care and Research and International Journal of Medical Science and Clinical Invention (IJMSCI) and He has been uploaded as an esteemed member of the Editorial Board at Universal Library of Chemistry. https://ulopenaccess.com/ulpages/editorialboardUlche ● Some websites for Loutfy H. Madkour: https://www.academia.edu/portfolio_preview/cv https://www.academia.edu/112507389/C_V_Loutfy_Hamed_Madkour https://www.scopus.com/authid/detail.uri?authorId=57201889680 https://orcid.org/0000-0002-3101-8356 https://www.semanticscholar.org/author/Loutfy-H.-Madkour/50815268 https://www.webofscience.com/wos/author/record/H-4810-2019 https://www.igi-global.com/affiliate/loutfy-madkour/443308?fbclid=IwAR0txBsapUKO7cffMPtE9FpezFwp4Jt1ypgcaGZzgM-mSFB7OiT6xftOsac ● Loutfy H. Madkour Prof. Loutfy H. Madkour: Professor of Physical chemistry, Nanoscience and Nanotechnology Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt E-mail address: loutfy_madkour@yahoo.com & lha.madkour@gmail.com Tel. +201026724286 (Egypt) & +20403355352