Márcio Lucas

Universidade Federal de Pernambuco, Centro De Ciências Biológicas, Graduate Student

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James Elkins

School of the Art Institute of Chicago

Eve Emshwiller

University of Wisconsin-Madison

David Seamon

Kansas State University

Tarek Kapiel

Cairo University

Shahira S Fahmy

American University in Cairo

William Cetzal-Ix

Instituto Tecnologico de Chiná

Francisco Paulo Jamil Marques

The University of Iowa

Roman Croitor

State University of Moldova

Vasily Gatov

University of Southern California

Juana María Coronado-Blanco

Universidad Autónoma de Tamaulipas

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Efeitos da intoxicação por lítio sobre a locomoção de ratos em um modelo animal de insuficiência renal aguda cirurgicamente induzido

Acta Cirurgica Brasileira, 2001

ABSTRACT

Protective effect of allopurinol in the renal ischemia–reperfusion in uninephrectomized rats

General Pharmacology-the Vascular System, 2000

The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfuncti... more The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia -reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia -reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia -reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemiareperfusion in uninephrectomized rats. D

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The Effects of Allopurinol in Hepatic Ischemia and Reperfusion: Experimental Study in Rats

European Surgical Research, 2000

Some studies have shown that postischemic hepatic dysfunction is mainly due to oxygen free radica... more Some studies have shown that postischemic hepatic dysfunction is mainly due to oxygen free radicals that are generated by xanthine oxidase. The present study was undertaken to determine the effect of allopurinol, an inhibitor of xanthine oxidase, on oxidative stress, liver injury and histologic alterations induced by hepatic ischemia-reperfusion in rats. One hundred and sixty Wistar rats were used and divided into three groups. Group 1: sham operation; group 2: 50 min of ischemia followed by 1 h of reperfusion, and group 3: pretreatment with allopurinol and 50 min of ischemia followed by 1 h of reperfusion. The effect of allopurinol was evaluated by plasma levels of alanine aminotransferase and aspartate aminotransferase, histopathologic studies, and lipid peroxidation measured by the thiobarbituric acid reactive substances method and chemiluminescence initiated by tert-butyl hydroperoxide technique. Ischemia followed by reperfusion promoted an increase in lipid peroxidation of the hepatic cells when compared to the sham-operated group (p&lt;0.05). This increase was attenuated in the group treated with allopurinol (p&lt; 0.05). Allopurinol also showed a protective effect on hepatocellular necrosis (p&lt;0.05), and the plasma levels of liver enzymes returned earlier to the normal range in rats pretreated with allopurinol in comparison to those that did not receive the drug (p&lt;0.05). Allopurinol exerted a protective effect on hepatic ischemia and reperfusion in rats. The administration of this drug prior to liver operations should be considered to be submitted to trials in humans.

Annona monograph revised

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Anaxagorea - Annonaceae

Anaxagorea is a critical genus for understanding morphological evolution in Annonaceae because it... more Anaxagorea is a critical genus for understanding morphological evolution in Annonaceae because it shares a variety of features with other Magnoliales that have been interpreted as primitive relative to other Annonaceae. We present a detailed discussion of morphological characters used in a combined morphological and molecular phylogenetic analysis of Anaxagorea, along with implications of the analysis for character evolution in the genus. In spite of a high level of homoplasy in stamen and leaf venation characters, their removal results in loss of resolution in the trees obtained. The distributions of characters on trees confirm assumptions that several distinctive similarities between Anaxagorea and other Magnoliales are primitive retentions (e.g., the presence of an adaxial plate of xylem in the midrib, nonpeltate stamen connectives, inner staminodes, and several leaf architectural characters). However, lateral extensions of the ''laminar'' stamens, though possibly ancestral in Anaxagorea, are convergent with those in other Magnoliales. A number of morphological synapomorphies have been identified for a clade containing most Central American species and another comprising all Asian species (e.g., conical bud shape and reduced inner petals for the Central American clade, and adaxial cuticular striations and capitate stigma shape for the Asian clade).

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Efeitos da intoxicação por lítio sobre a locomoção de ratos em um modelo animal de insuficiência renal aguda cirurgicamente induzido

Acta Cirurgica Brasileira, 2001

ABSTRACT

Protective effect of allopurinol in the renal ischemia–reperfusion in uninephrectomized rats

General Pharmacology-the Vascular System, 2000

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The Effects of Allopurinol in Hepatic Ischemia and Reperfusion: Experimental Study in Rats

European Surgical Research, 2000

Annona monograph revised

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Anaxagorea - Annonaceae

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