Papers by Laura Daniela Quintero
Neuroreport, 2008
Dopamine activates five different receptor subtypes and a complex array of intracellular signalin... more Dopamine activates five different receptor subtypes and a complex array of intracellular signaling pathways. Rhes is a striatally-expressed GTP-binding protein involved in dopamine signaling. Here we have used mutant mice to test whether Rhes is involved in D1 and D2 dopamine receptor-mediated behaviors. Rhes was not necessary for the expression of normal D1/D2 receptor synergism, as measured by apomorphine-induced stereotypy. The stereotypic responses to D1/D2 co-stimulation and to D2 stimulation alone were significantly increased in mice lacking Rhes, but D1 receptormediated grooming was reduced in these mice. These results suggest that Rhes is normally inhibitory to behaviors induced by D1/D2 receptor co-stimulation and by D2 receptor stimulation alone. However, Rhes appears to facilitate the D1-specific behavior of grooming.
Contenido de aprendizaje: Los contenidos de aprendizaje relacionados para el desarrollo de esta a... more Contenido de aprendizaje: Los contenidos de aprendizaje relacionados para el desarrollo de esta actividad, contienen elementos teóricos que ampliarán sus conocimientos permitiendo reflexionar frente a la significación o relevancia de la observación y la entrevista en la psicología.
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Papers by Laura Daniela Quintero