Directory

amr aly - Academia.edu

Skip to main content

amr aly

Followers

3

Following

2

Public Views

Fortis Escorts Heart Institute

MANYAM DELLIPRASAD REDDY

SASTRA University

Panagiotis Kourtesis

The American College of Greece Deree College

Ege University

The University of Sheffield

Oscar Campuzano

Universitat de Girona

University of South Alabama

University of Utah

Satienpong Huyanan

Mahanakorn University of Technology

University of East London

Interests

Uploads

Papers by amr aly

Model-Based Approaches to Channel Charting

We present new ways of producing a channel chart employing model-based approaches. We estimate th... more We present new ways of producing a channel chart employing model-based approaches. We estimate the angle of arrival θ and the distance between the base station and the user equipment ρ by employing our algorithms, inverse of the root sum squares of channel coefficients (ISQ) algorithm, linear regression (LR) algorithm, and the MUSIC/MUSIC (MM) algorithm. We compare these methods with the training-based channel charting algorithms principal component analysis (PCA), Samson's method (SM), and autoencoder (AE). We show that ISQ, LR, and MM outperform all three in performance. The performance of MM is better than LR and ISQ but it is more complex. ISQ and LR have similar performance with ISQ having less complexity than LR. We also compare our algorithm MM with an algorithm from the literature that uses the MUSIC algorithm jointly on θ and ρ. We call this algorithm the JM algorithm. JM performs very slightly better than MM but at a substantial increase in complexity. Finally, we introduce the rotate-and-sum (RS) algorithm which has about the same performance as the MM and JM algorithms but is less complex due to the avoidance of the eigenvector and eigenvalue analysis and a potential register transfer logic (RTL) implementation.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Frontiers in Molecular Neuroscience

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dy... more Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and functionality in different experimental models, the specific contribution of impaired activity to the neurodegenerative processes observed in ALS-related MN remains controversial. In particular, contrasting lines of evidence have shown both hyper- as well as hypoexcitability as driving pathomechanisms characterizing this specific neuronal population. In this study, we combined high definition multielectrode array (HD-MEA) techniques with transcriptomic analysis to longitudinally monitor and untangle the activity-dependent alterations arising in human C9orf72-mutant MN. We found a time-dependent reduction of neuronal activity in ALSC9orf72 cultures occurring as synaptic contacts undergo maturation and matched by a significant loss of mutant M...

Cost-effectiveness analysis of peri-implantitis non-surgical treatments in high-risk patients group and early economic evaluation of LABRIDA’s BioClean® device

Ensemble Data Analytics Approaches for Fast Parametrization Screening and Validation

Day 3 Wed, November 17, 2021, 2021

Ensemble approaches are increasingly used for history matching also with large scale models. Howe... more Ensemble approaches are increasingly used for history matching also with large scale models. However, the iterative nature and the high computational resources required, demands careful and consistent parameterization of the initial ensemble of models, to avoid repeated and time-consuming attempts before an acceptable match is achieved. The objective of this work is to introduce ensemble-based data analytic techniques to validate the starting ensemble and early identify potential parameterization problems, with significant time saving. These techniques are based on the same definition of the mismatch between the initial ensemble simulation results and the historical data used by ensemble algorithms. In fact, a notion of distance among ensemble realizations can be introduced using the mismatch, opening the possibility to use statistical analytic techniques like Multi-Dimensional Scaling and Generalized Sensitivity. In this way a clear and immediate view of ensemble behavior can be qu...

b Chemical Pathology, Medical Res

Introduction: Liver cancer is the sixth most common cancer worldwide. HCC is the most common prim... more Introduction: Liver cancer is the sixth most common cancer worldwide. HCC is the most common primary tumor of the liver. The National Comprehensive Cancer Network (NCCN) clinical practice guidelines for treatment of hepatobiliary cancers propose surveillance for the early detection of HCC by liver ultrasonography every 3-6 months and evaluation of AFP. AFP >200 ng/ml is considered diagnostic for HCC, although fewer than half of patients of HCC may generate levels that are high, so that the specificity of AFP is close to 100% but the sensitivity is 45%. Nitrite/Nitrate is a stable end product of nitric oxide increase in patients with HCC. Aim: It was to evaluate nitric oxide as a novel diagnostic marker for hepatocellular carcinoma. Methods: Eighty patients and 15 normal individuals enrolled in the study: Group (1) 15 normal individuals. Group (2) 30 patients with chronic liver disease without HCC. Group (3) 50 patients with HCC. History taking, clinical examination, (detection of liver masses, ascites, spleen size, and grade of encepathalopathy), and Child-pugh scoring. Laboratory investigation:

Synaptic disruption and CREB‐regulated transcription are restored by K + channel blockers in ALS

EMBO Molecular Medicine, 2021

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing ... more Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still under debate whether neuronal activity might represent a valid target for efficient therapies. In this study, we exploited a combination of transcriptomics, proteomics, optogenetics and pharmacological approaches to investigate the activity‐related pathological features of iPSC‐derived C9orf72‐mutant motoneurons (MN). We found that human ALSC9orf72 MN are characterized by accumulation of aberrant aggresomes, reduced expression of synaptic genes, loss of synaptic contacts and a dynamic “malactivation” of the transcription factor CREB. A similar phenotype was also found in TBK1‐mutant MN and upon overexpression of poly(GA) aggregates in primary neurons, indicating a strong convergence of pathological phenotypes on synaptic dysregulation. Notably, these alterations, along with neuronal survival, could be rescued by treating ALS‐related neurons with the K+ channel blockers Apamin and XE991, which, respectively, target the SK and the Kv7 channels. Thus, our study shows that restoring the activity‐dependent transcriptional programme and synaptic composition exerts a neuroprotective effect on ALS disease progression.

Unlocking Ensemble History Matching Potential with Parallelism and Careful Data Management

Day 3 Wed, November 17, 2021, 2021

Improvements in reservoir simulation computational time thanks to GPU-based simulators and the in... more Improvements in reservoir simulation computational time thanks to GPU-based simulators and the increasing computational power of modern HPC systems, are paving the way for a massive employment of Ensemble History Matching (EHM) techniques which are intrinsically parallel. Here we present the results of a comparative study between a newly developed EHM tool that aims at leveraging the GPU parallelism, and a commercial third-party EHM software as a benchmark. Both are tested on a real case. The reservoir chosen for the comparison has a production history of 3 years with 15 wells between oil producers, and water and gas injectors. The EHM algorithm used is the Ensemble Smoother with Multiple Data Assimilations (ESMDA) and both tools have access to the same computational resources. The EHM problem was stated in the same way for both tools. The objective function considers well oil productions, water cuts, bottom-hole pressures, and gas-oil-ratios. Porosity and horizontal permeability ar...

Conservative versus Surgical Treatment in Management of Closed Mallet Finger:A Systematic Review and MetaAnalysis

QJM: An International Journal of Medicine, 2021

Background Several methods of treatment have been mentioned in management of closed mallet finger... more Background Several methods of treatment have been mentioned in management of closed mallet finger injury, as conservative methods using stack splint,dorsal aluminum splint or custom thermoplastic splint, or surgical procedures as direct pinning method, extention block technique or hook plate fixation, there is no consensus for the best method of treatment. Objectives to review and meta-analyze the outcomes of conservative versus surgical treatment in management of closed mallet finger injury and statistically compare between their results of pain, extensor lag, range of motion of distal inter-phalangeal joint. Materials and Methods The review will be restricted to randomized controlled trials (RCTs), clinical trials, and comparative studies, either prospective or retrospective, which studied the outcome of conservative versus surgical treatment in management of closed mallet finger, articles published in English. PRISMA flow chart 950 articles were found using search keywords. By fi...

Reconstruction of Forearm, Wrist and Hand Skin Defects with Local Perforator Flaps

Ain Shams Medical Journal, 2019

Background: During the last decades, anatomical studies on skin vascularization provided the base... more Background: During the last decades, anatomical studies on skin vascularization provided the base for the development of flaps nourished by perforating arteries and preserving major vessels. In the last years, perforator flaps have become an appealing option for coverage of a large range of defects as they allow for great freedom in design and for reconstruction of difficult wounds with minimal donor-site morbidity, but doubts regarding their reliability have overshadowed its safety in clinical practice. Aim of the Work: This prospective clinical study is conducted to assess the reliability and efficacy of local perforator flaps in coverage of hand, wrist, and forearm skin defects. Patients and methods: We conducted a prospective study involving 20 patients with hand, wrist, and forearm skin defects and were covered with local radial and ulnar arteries perforator flaps. Postoperative complications were recorded and assessment of patients' satisfaction as regards donor site morbidity and aesthetic outcome of the flap was done by a questionnaire at the outpatient clinic and the results were classified as unsatisfactory, satisfactory, good, and very good. Vancouver Scar Scale was applied as an objective tool for scar assessment postoperative. Three-month follow up was the end point of this study. Results: Radial artery perforator flaps were done in 11 cases (55 %) and ulnar artery perforator flaps in 9 cases (45%).Temporary venous congestion happened in 19 cases, distal tip necrosis in 10 cases, superficial epidermolysis in 8 cases, and arterial insufficiency in one case. Mean operative time was 63.8 min., 70.64 min. in RA perforator flaps and 55.44 min. in UA perforator flaps. Conclusion: Perforator flaps are a reliable tool for upper extremity coverage, with a low rate of failure and secondary surgery. These flaps are particularly useful for covering small and medium sized defects in the distal one third of the forearm, wrist, and hand; and they represent a reliable and effective alternative to free flaps.

Conservative Treatment Versus Fixation of Type I Coronoid Fracture in Terrible Triad Injuries of the Elbow Joint

Ain Shams Medical Journal, 2020

Background: The coronoid process is considered the keystone of bony elbow stability, in addition ... more Background: The coronoid process is considered the keystone of bony elbow stability, in addition to its soft tissue attachment. Aim of the work: To compare conservative treatment versus fixation of type I coronoid fracture in terrible triad injuries as regard elbow stability, functional outcome, and possible complications. Patients and methods: We performed a prospective randomized control study on 20 patients with terrible triad injuries and were divided into two equal groups. Randomization was done using Microsoft Excel. Group (1) including 10 patients where the coronoid fracture was not repaired, and Group (2) including 10 patients where the coronoid fracture was repaired. All patients were operated using the lateral approach. In the second group, the coronoid fracture was fixed using pull-out sutures. In both groups, internal fixation was done for the radial head or neck fracture with reattachment of the lateral ulnar collateral ligament (LUCL) to its humeral origin by transosseous sutures. Postoperative patient assessment was done according to the Disabilities of the Arm, Shoulder and Hand (DASH) Score, and the Broberg-Morrey rating system. Results: In the first group, the mean Broberg-Morrey score was 91.2 (range, 85-98) with four excellent results and six good results. The average DASH score was 13 (range, 2.5-30). In the second group, the mean Broberg-Morrey score was 94.4 (range, 89-98) with seven excellent results and three good result. The average DASH score was 9.6 (range, 0-23.3).Two patients experienced postoperative complications in the first group, one implant failure of the radial neck fracture after 3 weeks follow up and the other did not reach complete union of his radial neck. Both patients refused a second operation. Conclusion: We conclude that fixation of type I coronoid fractures in terrible triad injuries did not show significant difference regarding elbow stability and clinical outcome at short-term follow up.

Reliability of propeller flaps in post-traumatic reconstruction of wrist and hand defects

European Journal of Orthopaedic Surgery & Traumatology, 2020

Purpose This is a purely observational study with a literature comparison to assess the effective... more Purpose This is a purely observational study with a literature comparison to assess the effectiveness of radial and ulnar arteries propeller perforator-based flaps in post-traumatic soft tissue reconstruction and identify the risk factors for complications. Methods Sixteen patients were involved with post-traumatic wrist and hand soft tissue defects not exceeding 5 × 20 cm. Defects were covered with propeller radial and ulnar arteries perforator-based flaps. Patient demographics, soft tissue defects, complications and clinical outcomes were recorded. Assessment of patients' satisfaction for donor site morbidity and aesthetic outcome of the flap were performed. Results Radial artery propeller perforator flap was performed in seven cases, and ulnar artery propeller perforator flap was done in nine cases. The size of the skin paddle ranged from 2.5 × 5 cm to 4.5 × 10.5 cm. Primary closure of the donor site was performed in all cases. One flap was lost, while superficial epidermolysis occurred in seven cases (45%). Edge necrosis ranging between 3 and 7 mm occurred in nine cases (60%). Patients' factors, mode of injury, associated injuries and interval between trauma and coverage were all correlated with complication incidence. The patients' satisfaction for donor site morbidity was very good and good in 80% of patients, while satisfaction for aesthetic outcome of the flap was very good and good in only 40%. Conclusion Radial and ulnar arteries have reliable perforators for flap elevation, which produce reliable outcome for smalland medium-sized soft tissue reconstruction. Effectiveness decreases in post-traumatic reconstructions. Complications are more frequent in crushing injuries especially if associated with bony fractures. Most complications in trauma cases were attributed to venous congestion, for which supercharging with a vein if accessible to the surgeon is recommended.

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Nature Neuroscience, 2019

Users may view, print, copy, and download text and data-mine the content in such documents, for t... more

The Effect of Applying Customer Relationship Management in the Higher Educational Sector

OALib, 2019

The purpose of this paper is to explore the effect of applying customer relationship management (... more The purpose of this paper is to explore the effect of applying customer relationship management (CRM) in the higher education sector. From the literature, four dimensions for measuring customer relationship management were suggested, which are: Knowledge Management, Interaction, Communication, and Feedback. The paper makes a recommendation for policymakers in the higher education sector to embrace investment in CRM.

Graphics Analysis of Gothic Vaults

High velocity powder thermal spray method for spraying non-meltable materials

Powder of plastic and treated mineral

<title>Health monitoring of complex structures</title>

Smart Structures and Materials 1998: Industrial and Commercial Applications of Smart Structures Technologies, 1998

ABSTRACT A basic step in the monitoring of health of any structure is detection of damage levels ... more ABSTRACT A basic step in the monitoring of health of any structure is detection of damage levels and location of the damage in the system. Several damage detection schemes have been proposed in recent years. Published applications of these methods are typically for simplified models of realistic structures. This leaves open the question of the accuracy and efficiency of the available damage detection methods when applied to large and complex structural models. This paper will investigate the accuracy of different damage detection techniques to complex structural models. A typical multi- jointed steel bridge, which is damaged by cracks of different sizes, is considered. The damage will be simulated analytically in the structural model, and the damage detection algorithms will be applied to both the damaged and the undamaged structures. Three damage detection algorithms are investigated, namely the change of stiffness, the change of flexibility and the damage index methods. Some modifications and extensions of the change of stiffness and change of flexibility methods were incorporated in this study. These extensions helped inaccurate comparisons between different methods. It was found that all three algorithms produced adequate damage detection results. More analytical studies are recommended. Also, experimental testing for complex structures is recommended.

Polypropylene Mesh for Recurrent Incisional Hernia: Different Operative Techniques

British Journal of Medicine and Medical Research, 2015

Aims: To locate the plane of mesh insertion whether it is onlay, inlay, sublay, or underlay. Desi... more Aims: To locate the plane of mesh insertion whether it is onlay, inlay, sublay, or underlay. Design: Prospective study Place and Duration: Done at Bani suef hospital between May 2011 till May 2012 with follow till May 2014. Methodology: Twenty two patients, six were males sixteen were females with recurrent incisional hernias were included in the study with a mean age ± SD of 44 years ± 11.87, there were 14 patients presented after the first recurrence (Groups 1, 2), 7 patients after the second recurrence Original Research Article Hamid et al.; BJMMR, 6(4): 423-430, 2015; Article no.BJMMR.2015.217 424 (Groups 3, 4) and only one for the third recurrence. There were no significant difference between patients presented by 1 st and 2 nd recurrence concerning the age, sex and level of hernia. To all patients a polypropylene mesh was applied, 12 onlay, 2 inlay, 5 sublay and 3 underlay. Results: There were two serosal lesions and only one perforation. There were 4(18%) patients with seroma, 1 (4.5%) with haematoma, 4 (18%) with infection, 3 (13.6%) with DVT, 1 (4.5%) with non fatal PE, and 1 (4.5%) respiratory failure. The highest incidence of complications were in the onlay repair, the lowest in the underlay repair. The patients were followed for two year, there were 6 recurrence (27.2%), most of them were in the onlay repair with the highest incidence in the inlay repair. The incidence of recurrence in the onlay to inlay was statistically non significant (P<0.5), the onlay to the sublay was significant (P<0.05) and the onlay to the underlay was highly significant (P<0.02). Conclusion: It is to be concluded that when a patient with recurrent incisional hernia is in need for repair, it is better to avoid inlay technique, not to do the underlay and the onlay techniques, and recommended to do the sublay approach.

Neuro-Oncology in Developing Countries

Neuro-Oncology, 2012

Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms... more Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms. Current standard management includes safe maximal surgical resection followed by craniospinal irradiation (CSI) with chemotherapeutic radiosensitization followed by adjuvant chemotherapy. The overall and event free survival rates depend upon many prognostic factors. PURPOSE: To investigate treatment outcome for newly diagnosed MB patients treated at the Children's Cancer Hospital Egypt 57357 (CCHE) and to determine the working prognostic factors. PATIENTS AND METHODS: This study included all patients; treated at the CCHE; with histologically confirmed MB between Jan, 2008, and Jan, 2011. The Median age of the 73 (49 males (67.1%); 24 females (32.9%)) patients was 7 years (range 3-17). The median follow up period was 16 months (range 1-41). Risk stratification based upon initial Chang's stage, degree of surgical resection and histopathology. All patients had surgical resection of the tumor. Seventy one patients (97.3%) received the allocated radiochemotherapy. One patient was lost follow up and one patient died before radiotherapy. Risk adapted treatment were performed via 2 treatment protocols (Standard and high risk). The 2 protocols differ in the dose of craniospinal irradiation and the chemotherapy regimen. RESULTS: The 3-year overall (OS) and event-free (EFS) survival differed significantly between average-risk and high-risk patients (p ¼ 0.024 and 0.003), with 77.8% and 82% OS and EFS for the average risk group respectively and 56.8 % and 50.5% OS and EFS for high-risk group respectively. The histopathology classification showed significant difference in both overall survivals: desmoplastic ¼ 75%, classic ¼ 71.6%, anaplastic ¼ 47.6%, (p ¼ 0.028) and event free survival: desmoplastic ¼ 75%, classic ¼ 68.9%, anaplastic ¼ 40.5%, (p ¼ 0.007). CONCLUSION: Preliminary results of risk adapted treatment for children suffering from medulloblastoma are encouraging and depending upon the clinical prognostic factors. Further follow up is needed to investigate further prognostic factors.

Model-Based Approaches to Channel Charting

We present new ways of producing a channel chart employing model-based approaches. We estimate th... more We present new ways of producing a channel chart employing model-based approaches. We estimate the angle of arrival θ and the distance between the base station and the user equipment ρ by employing our algorithms, inverse of the root sum squares of channel coefficients (ISQ) algorithm, linear regression (LR) algorithm, and the MUSIC/MUSIC (MM) algorithm. We compare these methods with the training-based channel charting algorithms principal component analysis (PCA), Samson's method (SM), and autoencoder (AE). We show that ISQ, LR, and MM outperform all three in performance. The performance of MM is better than LR and ISQ but it is more complex. ISQ and LR have similar performance with ISQ having less complexity than LR. We also compare our algorithm MM with an algorithm from the literature that uses the MUSIC algorithm jointly on θ and ρ. We call this algorithm the JM algorithm. JM performs very slightly better than MM but at a substantial increase in complexity. Finally, we introduce the rotate-and-sum (RS) algorithm which has about the same performance as the MM and JM algorithms but is less complex due to the avoidance of the eigenvector and eigenvalue analysis and a potential register transfer logic (RTL) implementation.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Frontiers in Molecular Neuroscience

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dy... more Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and functionality in different experimental models, the specific contribution of impaired activity to the neurodegenerative processes observed in ALS-related MN remains controversial. In particular, contrasting lines of evidence have shown both hyper- as well as hypoexcitability as driving pathomechanisms characterizing this specific neuronal population. In this study, we combined high definition multielectrode array (HD-MEA) techniques with transcriptomic analysis to longitudinally monitor and untangle the activity-dependent alterations arising in human C9orf72-mutant MN. We found a time-dependent reduction of neuronal activity in ALSC9orf72 cultures occurring as synaptic contacts undergo maturation and matched by a significant loss of mutant M...

Cost-effectiveness analysis of peri-implantitis non-surgical treatments in high-risk patients group and early economic evaluation of LABRIDA’s BioClean® device

Ensemble Data Analytics Approaches for Fast Parametrization Screening and Validation

Day 3 Wed, November 17, 2021, 2021

Ensemble approaches are increasingly used for history matching also with large scale models. Howe... more Ensemble approaches are increasingly used for history matching also with large scale models. However, the iterative nature and the high computational resources required, demands careful and consistent parameterization of the initial ensemble of models, to avoid repeated and time-consuming attempts before an acceptable match is achieved. The objective of this work is to introduce ensemble-based data analytic techniques to validate the starting ensemble and early identify potential parameterization problems, with significant time saving. These techniques are based on the same definition of the mismatch between the initial ensemble simulation results and the historical data used by ensemble algorithms. In fact, a notion of distance among ensemble realizations can be introduced using the mismatch, opening the possibility to use statistical analytic techniques like Multi-Dimensional Scaling and Generalized Sensitivity. In this way a clear and immediate view of ensemble behavior can be qu...

b Chemical Pathology, Medical Res

Introduction: Liver cancer is the sixth most common cancer worldwide. HCC is the most common prim... more Introduction: Liver cancer is the sixth most common cancer worldwide. HCC is the most common primary tumor of the liver. The National Comprehensive Cancer Network (NCCN) clinical practice guidelines for treatment of hepatobiliary cancers propose surveillance for the early detection of HCC by liver ultrasonography every 3-6 months and evaluation of AFP. AFP >200 ng/ml is considered diagnostic for HCC, although fewer than half of patients of HCC may generate levels that are high, so that the specificity of AFP is close to 100% but the sensitivity is 45%. Nitrite/Nitrate is a stable end product of nitric oxide increase in patients with HCC. Aim: It was to evaluate nitric oxide as a novel diagnostic marker for hepatocellular carcinoma. Methods: Eighty patients and 15 normal individuals enrolled in the study: Group (1) 15 normal individuals. Group (2) 30 patients with chronic liver disease without HCC. Group (3) 50 patients with HCC. History taking, clinical examination, (detection of liver masses, ascites, spleen size, and grade of encepathalopathy), and Child-pugh scoring. Laboratory investigation:

Synaptic disruption and CREB‐regulated transcription are restored by K + channel blockers in ALS

EMBO Molecular Medicine, 2021

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing ... more Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still under debate whether neuronal activity might represent a valid target for efficient therapies. In this study, we exploited a combination of transcriptomics, proteomics, optogenetics and pharmacological approaches to investigate the activity‐related pathological features of iPSC‐derived C9orf72‐mutant motoneurons (MN). We found that human ALSC9orf72 MN are characterized by accumulation of aberrant aggresomes, reduced expression of synaptic genes, loss of synaptic contacts and a dynamic “malactivation” of the transcription factor CREB. A similar phenotype was also found in TBK1‐mutant MN and upon overexpression of poly(GA) aggregates in primary neurons, indicating a strong convergence of pathological phenotypes on synaptic dysregulation. Notably, these alterations, along with neuronal survival, could be rescued by treating ALS‐related neurons with the K+ channel blockers Apamin and XE991, which, respectively, target the SK and the Kv7 channels. Thus, our study shows that restoring the activity‐dependent transcriptional programme and synaptic composition exerts a neuroprotective effect on ALS disease progression.

Unlocking Ensemble History Matching Potential with Parallelism and Careful Data Management

Day 3 Wed, November 17, 2021, 2021

Improvements in reservoir simulation computational time thanks to GPU-based simulators and the in... more Improvements in reservoir simulation computational time thanks to GPU-based simulators and the increasing computational power of modern HPC systems, are paving the way for a massive employment of Ensemble History Matching (EHM) techniques which are intrinsically parallel. Here we present the results of a comparative study between a newly developed EHM tool that aims at leveraging the GPU parallelism, and a commercial third-party EHM software as a benchmark. Both are tested on a real case. The reservoir chosen for the comparison has a production history of 3 years with 15 wells between oil producers, and water and gas injectors. The EHM algorithm used is the Ensemble Smoother with Multiple Data Assimilations (ESMDA) and both tools have access to the same computational resources. The EHM problem was stated in the same way for both tools. The objective function considers well oil productions, water cuts, bottom-hole pressures, and gas-oil-ratios. Porosity and horizontal permeability ar...

Conservative versus Surgical Treatment in Management of Closed Mallet Finger:A Systematic Review and MetaAnalysis

QJM: An International Journal of Medicine, 2021

Background Several methods of treatment have been mentioned in management of closed mallet finger... more Background Several methods of treatment have been mentioned in management of closed mallet finger injury, as conservative methods using stack splint,dorsal aluminum splint or custom thermoplastic splint, or surgical procedures as direct pinning method, extention block technique or hook plate fixation, there is no consensus for the best method of treatment. Objectives to review and meta-analyze the outcomes of conservative versus surgical treatment in management of closed mallet finger injury and statistically compare between their results of pain, extensor lag, range of motion of distal inter-phalangeal joint. Materials and Methods The review will be restricted to randomized controlled trials (RCTs), clinical trials, and comparative studies, either prospective or retrospective, which studied the outcome of conservative versus surgical treatment in management of closed mallet finger, articles published in English. PRISMA flow chart 950 articles were found using search keywords. By fi...

Reconstruction of Forearm, Wrist and Hand Skin Defects with Local Perforator Flaps

Ain Shams Medical Journal, 2019

Background: During the last decades, anatomical studies on skin vascularization provided the base... more Background: During the last decades, anatomical studies on skin vascularization provided the base for the development of flaps nourished by perforating arteries and preserving major vessels. In the last years, perforator flaps have become an appealing option for coverage of a large range of defects as they allow for great freedom in design and for reconstruction of difficult wounds with minimal donor-site morbidity, but doubts regarding their reliability have overshadowed its safety in clinical practice. Aim of the Work: This prospective clinical study is conducted to assess the reliability and efficacy of local perforator flaps in coverage of hand, wrist, and forearm skin defects. Patients and methods: We conducted a prospective study involving 20 patients with hand, wrist, and forearm skin defects and were covered with local radial and ulnar arteries perforator flaps. Postoperative complications were recorded and assessment of patients' satisfaction as regards donor site morbidity and aesthetic outcome of the flap was done by a questionnaire at the outpatient clinic and the results were classified as unsatisfactory, satisfactory, good, and very good. Vancouver Scar Scale was applied as an objective tool for scar assessment postoperative. Three-month follow up was the end point of this study. Results: Radial artery perforator flaps were done in 11 cases (55 %) and ulnar artery perforator flaps in 9 cases (45%).Temporary venous congestion happened in 19 cases, distal tip necrosis in 10 cases, superficial epidermolysis in 8 cases, and arterial insufficiency in one case. Mean operative time was 63.8 min., 70.64 min. in RA perforator flaps and 55.44 min. in UA perforator flaps. Conclusion: Perforator flaps are a reliable tool for upper extremity coverage, with a low rate of failure and secondary surgery. These flaps are particularly useful for covering small and medium sized defects in the distal one third of the forearm, wrist, and hand; and they represent a reliable and effective alternative to free flaps.

Conservative Treatment Versus Fixation of Type I Coronoid Fracture in Terrible Triad Injuries of the Elbow Joint

Ain Shams Medical Journal, 2020

Background: The coronoid process is considered the keystone of bony elbow stability, in addition ... more Background: The coronoid process is considered the keystone of bony elbow stability, in addition to its soft tissue attachment. Aim of the work: To compare conservative treatment versus fixation of type I coronoid fracture in terrible triad injuries as regard elbow stability, functional outcome, and possible complications. Patients and methods: We performed a prospective randomized control study on 20 patients with terrible triad injuries and were divided into two equal groups. Randomization was done using Microsoft Excel. Group (1) including 10 patients where the coronoid fracture was not repaired, and Group (2) including 10 patients where the coronoid fracture was repaired. All patients were operated using the lateral approach. In the second group, the coronoid fracture was fixed using pull-out sutures. In both groups, internal fixation was done for the radial head or neck fracture with reattachment of the lateral ulnar collateral ligament (LUCL) to its humeral origin by transosseous sutures. Postoperative patient assessment was done according to the Disabilities of the Arm, Shoulder and Hand (DASH) Score, and the Broberg-Morrey rating system. Results: In the first group, the mean Broberg-Morrey score was 91.2 (range, 85-98) with four excellent results and six good results. The average DASH score was 13 (range, 2.5-30). In the second group, the mean Broberg-Morrey score was 94.4 (range, 89-98) with seven excellent results and three good result. The average DASH score was 9.6 (range, 0-23.3).Two patients experienced postoperative complications in the first group, one implant failure of the radial neck fracture after 3 weeks follow up and the other did not reach complete union of his radial neck. Both patients refused a second operation. Conclusion: We conclude that fixation of type I coronoid fractures in terrible triad injuries did not show significant difference regarding elbow stability and clinical outcome at short-term follow up.

Reliability of propeller flaps in post-traumatic reconstruction of wrist and hand defects

European Journal of Orthopaedic Surgery & Traumatology, 2020

Purpose This is a purely observational study with a literature comparison to assess the effective... more Purpose This is a purely observational study with a literature comparison to assess the effectiveness of radial and ulnar arteries propeller perforator-based flaps in post-traumatic soft tissue reconstruction and identify the risk factors for complications. Methods Sixteen patients were involved with post-traumatic wrist and hand soft tissue defects not exceeding 5 × 20 cm. Defects were covered with propeller radial and ulnar arteries perforator-based flaps. Patient demographics, soft tissue defects, complications and clinical outcomes were recorded. Assessment of patients' satisfaction for donor site morbidity and aesthetic outcome of the flap were performed. Results Radial artery propeller perforator flap was performed in seven cases, and ulnar artery propeller perforator flap was done in nine cases. The size of the skin paddle ranged from 2.5 × 5 cm to 4.5 × 10.5 cm. Primary closure of the donor site was performed in all cases. One flap was lost, while superficial epidermolysis occurred in seven cases (45%). Edge necrosis ranging between 3 and 7 mm occurred in nine cases (60%). Patients' factors, mode of injury, associated injuries and interval between trauma and coverage were all correlated with complication incidence. The patients' satisfaction for donor site morbidity was very good and good in 80% of patients, while satisfaction for aesthetic outcome of the flap was very good and good in only 40%. Conclusion Radial and ulnar arteries have reliable perforators for flap elevation, which produce reliable outcome for smalland medium-sized soft tissue reconstruction. Effectiveness decreases in post-traumatic reconstructions. Complications are more frequent in crushing injuries especially if associated with bony fractures. Most complications in trauma cases were attributed to venous congestion, for which supercharging with a vein if accessible to the surgeon is recommended.

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Nature Neuroscience, 2019

Users may view, print, copy, and download text and data-mine the content in such documents, for t... more

The Effect of Applying Customer Relationship Management in the Higher Educational Sector

OALib, 2019

The purpose of this paper is to explore the effect of applying customer relationship management (... more The purpose of this paper is to explore the effect of applying customer relationship management (CRM) in the higher education sector. From the literature, four dimensions for measuring customer relationship management were suggested, which are: Knowledge Management, Interaction, Communication, and Feedback. The paper makes a recommendation for policymakers in the higher education sector to embrace investment in CRM.

Graphics Analysis of Gothic Vaults

High velocity powder thermal spray method for spraying non-meltable materials

Powder of plastic and treated mineral

<title>Health monitoring of complex structures</title>

Smart Structures and Materials 1998: Industrial and Commercial Applications of Smart Structures Technologies, 1998

ABSTRACT A basic step in the monitoring of health of any structure is detection of damage levels ... more ABSTRACT A basic step in the monitoring of health of any structure is detection of damage levels and location of the damage in the system. Several damage detection schemes have been proposed in recent years. Published applications of these methods are typically for simplified models of realistic structures. This leaves open the question of the accuracy and efficiency of the available damage detection methods when applied to large and complex structural models. This paper will investigate the accuracy of different damage detection techniques to complex structural models. A typical multi- jointed steel bridge, which is damaged by cracks of different sizes, is considered. The damage will be simulated analytically in the structural model, and the damage detection algorithms will be applied to both the damaged and the undamaged structures. Three damage detection algorithms are investigated, namely the change of stiffness, the change of flexibility and the damage index methods. Some modifications and extensions of the change of stiffness and change of flexibility methods were incorporated in this study. These extensions helped inaccurate comparisons between different methods. It was found that all three algorithms produced adequate damage detection results. More analytical studies are recommended. Also, experimental testing for complex structures is recommended.

Polypropylene Mesh for Recurrent Incisional Hernia: Different Operative Techniques

British Journal of Medicine and Medical Research, 2015

Aims: To locate the plane of mesh insertion whether it is onlay, inlay, sublay, or underlay. Desi... more Aims: To locate the plane of mesh insertion whether it is onlay, inlay, sublay, or underlay. Design: Prospective study Place and Duration: Done at Bani suef hospital between May 2011 till May 2012 with follow till May 2014. Methodology: Twenty two patients, six were males sixteen were females with recurrent incisional hernias were included in the study with a mean age ± SD of 44 years ± 11.87, there were 14 patients presented after the first recurrence (Groups 1, 2), 7 patients after the second recurrence Original Research Article Hamid et al.; BJMMR, 6(4): 423-430, 2015; Article no.BJMMR.2015.217 424 (Groups 3, 4) and only one for the third recurrence. There were no significant difference between patients presented by 1 st and 2 nd recurrence concerning the age, sex and level of hernia. To all patients a polypropylene mesh was applied, 12 onlay, 2 inlay, 5 sublay and 3 underlay. Results: There were two serosal lesions and only one perforation. There were 4(18%) patients with seroma, 1 (4.5%) with haematoma, 4 (18%) with infection, 3 (13.6%) with DVT, 1 (4.5%) with non fatal PE, and 1 (4.5%) respiratory failure. The highest incidence of complications were in the onlay repair, the lowest in the underlay repair. The patients were followed for two year, there were 6 recurrence (27.2%), most of them were in the onlay repair with the highest incidence in the inlay repair. The incidence of recurrence in the onlay to inlay was statistically non significant (P<0.5), the onlay to the sublay was significant (P<0.05) and the onlay to the underlay was highly significant (P<0.02). Conclusion: It is to be concluded that when a patient with recurrent incisional hernia is in need for repair, it is better to avoid inlay technique, not to do the underlay and the onlay techniques, and recommended to do the sublay approach.

Neuro-Oncology in Developing Countries

Neuro-Oncology, 2012

Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms... more Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms. Current standard management includes safe maximal surgical resection followed by craniospinal irradiation (CSI) with chemotherapeutic radiosensitization followed by adjuvant chemotherapy. The overall and event free survival rates depend upon many prognostic factors. PURPOSE: To investigate treatment outcome for newly diagnosed MB patients treated at the Children's Cancer Hospital Egypt 57357 (CCHE) and to determine the working prognostic factors. PATIENTS AND METHODS: This study included all patients; treated at the CCHE; with histologically confirmed MB between Jan, 2008, and Jan, 2011. The Median age of the 73 (49 males (67.1%); 24 females (32.9%)) patients was 7 years (range 3-17). The median follow up period was 16 months (range 1-41). Risk stratification based upon initial Chang's stage, degree of surgical resection and histopathology. All patients had surgical resection of the tumor. Seventy one patients (97.3%) received the allocated radiochemotherapy. One patient was lost follow up and one patient died before radiotherapy. Risk adapted treatment were performed via 2 treatment protocols (Standard and high risk). The 2 protocols differ in the dose of craniospinal irradiation and the chemotherapy regimen. RESULTS: The 3-year overall (OS) and event-free (EFS) survival differed significantly between average-risk and high-risk patients (p ¼ 0.024 and 0.003), with 77.8% and 82% OS and EFS for the average risk group respectively and 56.8 % and 50.5% OS and EFS for high-risk group respectively. The histopathology classification showed significant difference in both overall survivals: desmoplastic ¼ 75%, classic ¼ 71.6%, anaplastic ¼ 47.6%, (p ¼ 0.028) and event free survival: desmoplastic ¼ 75%, classic ¼ 68.9%, anaplastic ¼ 40.5%, (p ¼ 0.007). CONCLUSION: Preliminary results of risk adapted treatment for children suffering from medulloblastoma are encouraging and depending upon the clinical prognostic factors. Further follow up is needed to investigate further prognostic factors.