Wiliam Wiliam

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Yuksel Goktas

Ataturk University

David Seamon

Kansas State University

Ramesh Chander Sharma

Ambedkar University Delhi

Armando Marques-Guedes

UNL - New University of Lisbon

Michael W Charney

SOAS University of London

Patrick Lowenthal

Boise State University

Thongchai Winichakul ธงชัย วินิจจะกูล

University of Wisconsin-Madison

Tyrell Haberkorn

University of Wisconsin-Madison

Irina Kolesnik

Moscow State University

Andrea Acri

Ecole Pratique des Hautes Etudes

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Papers by Wiliam Wiliam

EFECTIVIDAD DE INTERVENCIONES COMUNITARIAS EN LA REDUCCIÓN DEL COMPORTAMIENTO AGRESIVO DE LOS NIÑOS MATRICULADOS EN PEREIRA, DURANTE EL AÑO 2006

Educational reform and primary and secondary teachers' conceptions of assessment: the Spanish instance, building upon Black and Wiliam (2005

Curriculum Journal, 2007

The author intends to add one particular national point of view to a previous comparative reflect... more The author intends to add one particular national point of view to a previous comparative reflection done by Black and Wiliam (2005), whose thesis is the need to study particular cases before making general proposals addressing the implementation of formative assessment practices. Teachers' conceptions about assessment are considered to be one important factor of pedagogical reform in classrooms. The structure of the educational system is recognized as another important element to be looked at. Fifty teachers from Barcelona city and the surrounding area were interviewed, thirty from primary schools and twenty from secondary schools. Additionally, classroom material which the teachers felt to be significantly representative of their daily assessment practices was demanded from them. A qualitative content analysis allowed the author to define five conceptions about assessment along one continuum, containing four different dimensions. Results reveal important differences between primary and secondary teachers as to their conceptions of assessment, which the author links to the structural changes of the national educational system back in the early 1990s. These differences should be taken into account if significant changes towards a generalization of formative assessment are expected to happen.

In)dependência funcional na dependente relação de homens tetraplégicos com seus (in)substituíveis pais/cuidadores

Revista Da Associacao Medica Brasileira, 2010

Objetivou-se identificar elementos da classificação internacional de funcionalidade, incapacidade... more Objetivou-se identificar elementos da classificação internacional de funcionalidade, incapacidade e saúde, aplicáveis ao cuidado domiciliar de homens adultos tetraplégicos, com vistas à redução da dependência de ajuda de seus pais para as atividades da vida diária, e o autocuidado. Os dados foram coletados de junho de 2004 a março de 2005, a partir de entrevista semi-estruturada, realizada com 8 adultos acometidos de lesão medular alta, e com experiência de usuários do cuidado domiciliar. Optou-se pela análise de conteúdo, a partir das categorias de significados pautadas nos seguintes resultados: suporte familiar: segurança para as funções corporais do incapacitado; tecnologia assistiva: inventividades para promoção da qualidade do cuidado; medos, futuro incerto e perda dos pais: limiares e fragilidades humanas; e ganhos funcionais: respostas objetivas das funções corporais. Conclui-se que o apoio da família e, em especial, a presença dos pais, são fundamentais para enfrentar as limitações e reagir na busca de equilíbrio na deficiência, incapacidade, desvantagem e saúde dessa clientela, preparando-a para o alcance de gradativos ganhos funcionais e independência para atividades cotidianas e autocuidado.

Fast purification of the Apo form and of a non-binding heme mutant of recombinant sperm whale myoglobin

Protein Expression and Purification, 2003

As molecular biology has developed it has become possible to abundantly produce heterologous prot... more As molecular biology has developed it has become possible to abundantly produce heterologous proteins in bacteria and to design serial amino acid substitutions for the generation of modified proteins, an approach also known as protein engineering. Sperm whale myoglobin, a protein of broad interest, has been cloned for several years now and a large collection of mutants has been produced. The presence of heme stabilizes the protein, which is recovered soluble from the bacterial pellet, and most purification protocols take advantage of this property for myoglobin purification directly from the pellet. However, recovery from the column resin is poor with these methods making them expensive and the procedure for removing heme is laborious and drastic when the apo form of Mb is required. In the case of proteins with severe mutations, which bind heme weakly or do not bind it at all, such methods cannot be employed without massive loss of productivity. Here, we describe a modified method, which is both low cost and rapid, for the purification of the soluble apo form of Mb from Escherichia coli inclusion bodies. Biophysical characterization of the protein after purification shows that the purified apoMb retains its native conformation and is soluble. This modified method is also used for the purification of a non-heme-binding apoMb mutant, demonstrating its efficiency when dealing with drastic mutations.

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The Nature and Value of Formative Assessment for Learning

The this paper has two foci. The first is to present an account of how we developed formative ass... more The this paper has two foci. The first is to present an account of how we developed formative assessment practices with a group of 36 teachers. This is then complemented by a reflection on the productive and positive experience of these teachers, in the light of learning principles, of changes in the roles of teachers and pupils in the task of learning, and of effects on the self-esteem and motivation of pupils. Attention then shifts to the second focus, which is on the ways in which these teachers struggled with the interface between formative assessment and summative testing. The conclusion is that the potential of enhanced classroom assessment to raise standards may never be fully realised unless the regimes of assessment for the purposes of accountability and certification of pupils are reformed.

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Stability and folding studies of the N-domain of troponin C. Evidence for the formation of an intermediate

Archives of Biochemistry and Biophysics, 2004

We report here on the stability and folding of the 91 residue a-helical F29W N-terminal domain of... more We report here on the stability and folding of the 91 residue a-helical F29W N-terminal domain of chicken skeletal muscle troponin C (TnC 1-91 F29W), the thin filament calcium-binding component. Unfolding was monitored by differential scanning calorimetry, circular dichroism, and intrinsic fluorescence spectroscopy using urea, pH, and temperature as denaturants, in the absence and in the presence of calcium. The unfolding of TnC 1-91 F29W was reversible and did not follow a two-state transition, suggesting that an intermediate may be present during this reaction. Our results support the hypothesis that intermediates are likely to occur during the folding of small proteins and domains. The physiological significance of the presence of an intermediate in the folding pathway of troponin C is discussed. (C.H.I. Ramos). 1 Abbreviations used: N-TnC, N-domain (residues 1-91) Troponin C; C m , urea concentration at the midpoint of the unfolding transition; T m , temperature of the midpoint of the thermal unfolding transition; CD, circular dichroism; [H], mean residue molar ellipticity; DSC, differential scanning calorimetry; DH cal , enthalpy of unfolding, DH vH , vanÕt Hoff enthalpy; Gdm-Cl, guanidinium chloride.

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