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Mario Sandoval

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Armando Marques-Guedes

UNL - New University of Lisbon

Dominic D'Agostino

University of South Florida

National Scientific and Technical Research Council

Eduardo G Pérez-Yarza

Universidad del País Vasco UPV/EHU

Universidad de Extremadura

Edwin-Francisco Herrera-Paz

Universidad Catolica de Honduras

Jose Ángel Planillo Portolés

Universidade Federal do Rio de Janeiro (UFRJ)

ZULMA CONSUELO URREGO MENDOZA

Universidad Nacional de Colombia (National University of Colombia)

EDUARDO G PEREZ-YARZA

Universidad del País Vasco UPV/EHU

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Papers by Mario Sandoval

Increasing the level of certainty in medical diagnosis. Using AHP/ANP with compatibility index G in support of medical diagnosis

International Journal of Medical Engineering and Informatics, 2016

This paper is based on the development of a web-based tool, in support of medical decision making... more This paper is based on the development of a web-based tool, in support of medical decision making called medical sapiens (MS), oriented to improve diagnostic accuracy and diminishing the uncertainty of the initial diagnosis. It has been developed for four years working with several senior physicians from Medicine Faculty of Los Andes University, and is currently being installed in a public hospital and in a private sport centre in Santiago in its testing mode. The results of this work show that medical certainty grows up significantly when applying this new approach for the diagnosis issue, mainly due to its better way of coping to intrinsic complexity.

Using Ahp/Anp in Support of Medical Diagnosis

by Mario Sandoval and Claudio Garuti

Using Ahp/Anp in Support of Medical Diagnosis

Proceedings of the International Symposium on the Analytic Hierarchy Process

Efectos del consumo de antioxidantes en exposición a altitud

redsalud.gov.cl

Efectos del consumo de antioxidantes en exposición a altitud RESUMEN £1 objetivo de este estudio ... more

Hypobaric hypoxia-reoxygenation diminishes band 3 protein functions in human erythrocytes

Pfl�gers Archiv European Journal of Physiology, 2002

We have previously shown that subjects exposed to acute hypobaric hypoxia display an erythrocyte ... more We have previously shown that subjects exposed to acute hypobaric hypoxia display an erythrocyte membrane protein band 3 with an increased susceptibility to proteolytic degradation. We suggested it was due to an oxidative damage of band 3. We now report that exposure to hypobaric hypoxia followed by reoxygenation affects protein band 3 functions such as anion transport and binding of glyceraldehyde-3P-dehydrogenase. Transport capacity was assessed with the fluorescent probe 2-[N-(7nitrobenz-2-oxa-1,3-diazol-4-yl)amino] ethanesulfonate (NBD-taurine). Binding capacity was evaluated from the activity of the membrane-associated enzyme. Healthy young men were exposed for 20 min to hypobaric hypoxia, simulating an altitude of 4,500 m above sea level and after recompression band 3 function was assessed. An inhibition of band 3 anion transport function and a decrease in the binding of glyceraldehyde-3Pdehydrogenase to band 3 were observed. Evidence is given supporting the hypothesis that functional alteration of band 3 is due to its oxidative modification originated as a consequence of the exposure to hypobaric hypoxia and further reoxygenation.

Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Mediators of Inflammation, 2010

Arsenic has been associated with multiple harmful effects at the cellular level. Indirectly these... more Arsenic has been associated with multiple harmful effects at the cellular level. Indirectly these defects could be related to impairment of the integrity of the immune system, in particular in lymphoid population. To characterize the effect of Arsenic on redox status on this population, copper smelter workers and arsenic unexposed donors were recruited for this study. We analyzed urine samples and lymphocyte enriched fractions from donors to determinate arsenic levels and lymphocyte proliferation. Moreover, we studied the presence of oxidative markers MDA, vitamin E and SOD activity in donor plasma. Here we demonstrated that in human beings exposed to high arsenic concentrations, lymphocyte MDA and arsenic urinary levels showed a positive correlation with SOD activity, and a negative correlation with vitamin E serum levels. Strikingly, lymphocytes from the arsenic exposed population respond to a polyclonal stimulator, phytohemaglutinin, with higher rates of thymidine incorporation than lymphocytes of a control population. As well, similar in vitro responses to arsenic were observed using a T cell line. Our results suggest that chronic human exposure to arsenic induces oxidative damage in lymphocytes and could be considered more relevant than evaluation of T cell surveillance.

Increasing the level of certainty in medical diagnosis. Using AHP/ANP with compatibility index G in support of medical diagnosis

by Mario Sandoval and Claudio Garuti

International Journal of Medical Engineering and Informatics, 2016

The AHP: A multicriteria decision making methodology for shiftwork prioritizing

by Claudio Garuti and Mario Sandoval

Journal of Systems Science and Systems Engineering, 2006

COMPARING AHP AND ANP SHIFTWORK MODELS: HIERARCHY SIMPLICITY V/S NETWORK CONNECTIVITY

by Claudio Garuti and Mario Sandoval

... Claudio Garuti and Mario Sandoval Fulcrum Engineering Ltd. Luis Thayer Ojeda 0180 Of.1004 – S... more

Revisión bibliográfica para elaboración de normativa de trabajo en altitud intermitente crónica

Medwave, 2014

The AHP: A multicriteria decision making methodology for shiftwork prioritizing

by Mario Sandoval and Claudio Garuti

Journal of Systems Science and Systems Engineering, 2006

Director Centro de Ergonomía del Trabajo Humano en Altitud CETHA- ACHS

Sueño y Trabajo en Altitud

Enfermedad Aguda de Montaña Enfermedad Aguda de Montaña (EAM

Director Centro de Ergonomía del Trabajo Humano en Altitud CETHA- ACHS

Increasing the level of certainty in medical diagnosis. Using AHP/ANP with compatibility index G in support of medical diagnosis

International Journal of Medical Engineering and Informatics, 2016

This paper is based on the development of a web-based tool, in support of medical decision making... more This paper is based on the development of a web-based tool, in support of medical decision making called medical sapiens (MS), oriented to improve diagnostic accuracy and diminishing the uncertainty of the initial diagnosis. It has been developed for four years working with several senior physicians from Medicine Faculty of Los Andes University, and is currently being installed in a public hospital and in a private sport centre in Santiago in its testing mode. The results of this work show that medical certainty grows up significantly when applying this new approach for the diagnosis issue, mainly due to its better way of coping to intrinsic complexity.

Using Ahp/Anp in Support of Medical Diagnosis

by Mario Sandoval and Claudio Garuti

Using Ahp/Anp in Support of Medical Diagnosis

Proceedings of the International Symposium on the Analytic Hierarchy Process

Efectos del consumo de antioxidantes en exposición a altitud

redsalud.gov.cl

Efectos del consumo de antioxidantes en exposición a altitud RESUMEN £1 objetivo de este estudio ... more

Hypobaric hypoxia-reoxygenation diminishes band 3 protein functions in human erythrocytes

Pfl�gers Archiv European Journal of Physiology, 2002

We have previously shown that subjects exposed to acute hypobaric hypoxia display an erythrocyte ... more We have previously shown that subjects exposed to acute hypobaric hypoxia display an erythrocyte membrane protein band 3 with an increased susceptibility to proteolytic degradation. We suggested it was due to an oxidative damage of band 3. We now report that exposure to hypobaric hypoxia followed by reoxygenation affects protein band 3 functions such as anion transport and binding of glyceraldehyde-3P-dehydrogenase. Transport capacity was assessed with the fluorescent probe 2-[N-(7nitrobenz-2-oxa-1,3-diazol-4-yl)amino] ethanesulfonate (NBD-taurine). Binding capacity was evaluated from the activity of the membrane-associated enzyme. Healthy young men were exposed for 20 min to hypobaric hypoxia, simulating an altitude of 4,500 m above sea level and after recompression band 3 function was assessed. An inhibition of band 3 anion transport function and a decrease in the binding of glyceraldehyde-3Pdehydrogenase to band 3 were observed. Evidence is given supporting the hypothesis that functional alteration of band 3 is due to its oxidative modification originated as a consequence of the exposure to hypobaric hypoxia and further reoxygenation.

Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Mediators of Inflammation, 2010

Arsenic has been associated with multiple harmful effects at the cellular level. Indirectly these... more Arsenic has been associated with multiple harmful effects at the cellular level. Indirectly these defects could be related to impairment of the integrity of the immune system, in particular in lymphoid population. To characterize the effect of Arsenic on redox status on this population, copper smelter workers and arsenic unexposed donors were recruited for this study. We analyzed urine samples and lymphocyte enriched fractions from donors to determinate arsenic levels and lymphocyte proliferation. Moreover, we studied the presence of oxidative markers MDA, vitamin E and SOD activity in donor plasma. Here we demonstrated that in human beings exposed to high arsenic concentrations, lymphocyte MDA and arsenic urinary levels showed a positive correlation with SOD activity, and a negative correlation with vitamin E serum levels. Strikingly, lymphocytes from the arsenic exposed population respond to a polyclonal stimulator, phytohemaglutinin, with higher rates of thymidine incorporation than lymphocytes of a control population. As well, similar in vitro responses to arsenic were observed using a T cell line. Our results suggest that chronic human exposure to arsenic induces oxidative damage in lymphocytes and could be considered more relevant than evaluation of T cell surveillance.

Increasing the level of certainty in medical diagnosis. Using AHP/ANP with compatibility index G in support of medical diagnosis

by Mario Sandoval and Claudio Garuti

International Journal of Medical Engineering and Informatics, 2016

The AHP: A multicriteria decision making methodology for shiftwork prioritizing

by Claudio Garuti and Mario Sandoval

Journal of Systems Science and Systems Engineering, 2006

COMPARING AHP AND ANP SHIFTWORK MODELS: HIERARCHY SIMPLICITY V/S NETWORK CONNECTIVITY

by Claudio Garuti and Mario Sandoval

... Claudio Garuti and Mario Sandoval Fulcrum Engineering Ltd. Luis Thayer Ojeda 0180 Of.1004 – S... more

Revisión bibliográfica para elaboración de normativa de trabajo en altitud intermitente crónica

Medwave, 2014

The AHP: A multicriteria decision making methodology for shiftwork prioritizing

by Mario Sandoval and Claudio Garuti

Journal of Systems Science and Systems Engineering, 2006

Director Centro de Ergonomía del Trabajo Humano en Altitud CETHA- ACHS

Sueño y Trabajo en Altitud

Enfermedad Aguda de Montaña Enfermedad Aguda de Montaña (EAM

Director Centro de Ergonomía del Trabajo Humano en Altitud CETHA- ACHS