East Tennessee State University
Department of Medical Education
This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the... more
A 7-month-old girl with congenital cytomegalovirus (CMV) infection underwent an immune assessment in anticipation of Transfer Factor therapy. She had been symptomatic since birth, with jaundice, rhinorrhea, diarrhea, pneumonia,... more
A 5-year-old boy was diagnosed as having chronic mucocu-taneous candidiasis at the age of three months. He showed no improvement despite treatment with two courses of intravenous amphotericin B, 2½ years of oral 5-fluorocytosine, and... more
LTHOUGH THE AGE-ADJUSTED death rate due to cardiovascular disease (CVD) has declined in the past 25 years, heart disease remains the leading cause of death in the United States, accounting for 733 834 deaths, or 31.6% of total mortality,... more
We have previously reported that exercise-related secretion of IL-6 by peripheral blood mononuclear cells is proportionate to body weight, suggesting that IL-6 is gravisensitive and that suboptimal production of this key cytokine may... more
Astronauts at are risk of losing 1.0-1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all... more
This article provides a brief review of the pathophysiology of osteoarthritis and the ontogeny of chondrocytes and details how physical exercise improves the health of osteoarthritic joints and enhances the potential of autologous... more
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of... more
Tumor necrosis factor alpha (TNF-α), a proinflammatory/proatherogenic cytokine, has been implicated as the cause hyperlipidemia in patients with chronic inflammatory joint disease including rheumatoid arthritis, psoriatic arthritis and... more
Case Report IJCR (2020) 4:156 Meningoencephalitis in a Child with Mycoplasma Pneumonia The patient is a 15-year-old girl who presented with a 4-day history of fever, a persistent cough, and x-ray evidence of a right middle lobe pneumonia.... more
The microgravity of space has a number of detrimental effects on the central nervous system of astronauts and cosmonauts. This includes the development of increased intracranial pressure and cerebrospinal fluid volume, thickening of the... more
The complex regional pain syndrome (CRPS) is a chronic pain condition characterized by peripheral and central nervous system dysregulation with consequent persistent cutaneous hyperalgesia and allodynia. Although usually involving an... more
Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study... more
Abstract The microgravity of space has a number of detrimental effects on the central nervous system of astronauts and cosmonauts. This includes the development of increased intracranial pressure and cerebrospinal fluid volume,... more