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East Tennessee State University | Department of Medical Education - Academia.edu
This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the... more
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      Exercise PhysiologySport And Exercise PsychologyExercise ScienceExercise and physical activity for health
A 7-month-old girl with congenital cytomegalovirus (CMV) infection underwent an immune assessment in anticipation of Transfer Factor therapy. She had been symptomatic since birth, with jaundice, rhinorrhea, diarrhea, pneumonia,... more
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    • Immunotherapy
A 5-year-old boy was diagnosed as having chronic mucocu-taneous candidiasis at the age of three months. He showed no improvement despite treatment with two courses of intravenous amphotericin B, 2½ years of oral 5-fluorocytosine, and... more
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      ImmunotherapyCHRONIC MUCOCUTANEOUS CANDIDIASIS
LTHOUGH THE AGE-ADJUSTED death rate due to cardiovascular disease (CVD) has declined in the past 25 years, heart disease remains the leading cause of death in the United States, accounting for 733 834 deaths, or 31.6% of total mortality,... more
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      RiskCytokinesExerciseC reactive protein
We have previously reported that exercise-related secretion of IL-6 by peripheral blood mononuclear cells is proportionate to body weight, suggesting that IL-6 is gravisensitive and that suboptimal production of this key cytokine may... more
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Astronauts at are risk of losing 1.0-1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all... more
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      Insulin-like Growth Factor-IMicrogravity
This article provides a brief review of the pathophysiology of osteoarthritis and the ontogeny of chondrocytes and details how physical exercise improves the health of osteoarthritic joints and enhances the potential of autologous... more
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    • Cartilage Tissue Engineering
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of... more
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    • Osteoclasts
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    • Osteochondral Tissue Engineering
Tumor necrosis factor alpha (TNF-α), a proinflammatory/proatherogenic cytokine, has been implicated as the cause hyperlipidemia in patients with chronic inflammatory joint disease including rheumatoid arthritis, psoriatic arthritis and... more
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    • Exercise Physiology
Case Report IJCR (2020) 4:156 Meningoencephalitis in a Child with Mycoplasma Pneumonia The patient is a 15-year-old girl who presented with a 4-day history of fever, a persistent cough, and x-ray evidence of a right middle lobe pneumonia.... more
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    • Mycoplasma pneumoniae
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    • Sneezing
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    • Geckos
The microgravity of space has a number of detrimental effects on the central nervous system of astronauts and cosmonauts. This includes the development of increased intracranial pressure and cerebrospinal fluid volume, thickening of the... more
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      MicrogravitySpace TravelASTRONAUTSCNS disorders
The complex regional pain syndrome (CRPS) is a chronic pain condition characterized by peripheral and central nervous system dysregulation with consequent persistent cutaneous hyperalgesia and allodynia. Although usually involving an... more
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      Chronic PainMuscle atrophy and countermeasuresClubbingInjury Management
On the afternoon of February 15, 2013, Asteroid 2012 DA14 entered the Earth’s vicinity just as predicted by NASA scientists. Discovered on February 23, 2012, by the Observatorio Astronomico de La Sagra in Granada, Spain, Asteroid 2012... more
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      RadiationSolarASTRONAUTS
Background: The effect of birth season climate on adult IgE-mediated respiratory disease is an important public health issue. Objective: To determine the effect of birth season climate on adult total serum IgE (TSIgE) levels. Study... more
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      ClimatologyAllergyPediatrics and Child HealthIGE
Abstract The microgravity of space has a number of detrimental effects on the central nervous system of astronauts and cosmonauts. This includes the development of increased intracranial pressure and cerebrospinal fluid volume,... more
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      Space flightMicrogliaMicrogravityCentral Nervous System